Cereulide synthetase gene cluster from emetic Bacillus cereus: Structure and location on a mega virulence plasmid related to Bacillus anthracis toxin plasmid pXO1 |
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| Authors: | Monika Ehling-Schulz Martina Fricker Harald Grallert Petra Rieck Martin Wagner Siegfried Scherer |
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| Affiliation: | 1. Lehrstuhl für Mikrobielle ?kologie, Department für Biowissenschaftliche Grundlagen, WZW, Technische Universit?t München, Freising, Germany
2. Institute of Milk Hygiene, Milk Technology and Food Science, University of Veterinary Medicine, Vienna, Austria
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| Abstract: | Background Cereulide, a depsipeptide structurally related to valinomycin, is responsible for the emetic type of gastrointestinal disease caused by Bacillus cereus. Recently, it has been shown that this toxin is produced by a nonribosomal peptide synthetase (NRPS), but its exact genetic organization and biochemical synthesis is unknown. |
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