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Cereulide synthetase gene cluster from emetic Bacillus cereus: Structure and location on a mega virulence plasmid related to Bacillus anthracis toxin plasmid pXO1
Authors:Monika Ehling-Schulz  Martina Fricker  Harald Grallert  Petra Rieck  Martin Wagner  Siegfried Scherer
Institution:1. Lehrstuhl für Mikrobielle ?kologie, Department für Biowissenschaftliche Grundlagen, WZW, Technische Universit?t München, Freising, Germany
2. Institute of Milk Hygiene, Milk Technology and Food Science, University of Veterinary Medicine, Vienna, Austria
Abstract:

Background  

Cereulide, a depsipeptide structurally related to valinomycin, is responsible for the emetic type of gastrointestinal disease caused by Bacillus cereus. Recently, it has been shown that this toxin is produced by a nonribosomal peptide synthetase (NRPS), but its exact genetic organization and biochemical synthesis is unknown.
Keywords:
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