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Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: Implications for metabolism research
Authors:Katrin Martens
Institution:Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K.U. Leuven, Leuven, Belgium
Abstract:aP2-Cre mice have amply been used to generate conditional adipose selective inactivation of important signaling molecules. We show that the efficiency of Cre mediated recombination in adipocytes and adipose selectivity is not always guaranteed. In particular, Cre activity was found in ganglia of the peripheral nervous system (PNS), in adrenal medulla and in neurons throughout the central nervous system (CNS). Because these tissues have an important impact on adipose tissue, care should be taken when using aP2-Cre mice to define the role of the targeted genes in adipose tissue function.
Keywords:BAT  brown adipose tissue  CNS  central nervous system  FABP  fatty acid binding protein  GFAP  glial acidic fibrillary protein  β-gal  β-galactosidase  NeuN  neuronal nuclei  PBS  phosphate buffered saline  PNS  peripheral nervous system  WAT  white adipose tissue
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