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Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins |
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| Authors: | Morihisa Fujita Taroh Kinoshita |
| Institution: | a Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan b WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan c Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan |
| Abstract: | Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved post-translational modification in eukaryotes. In mammalian cells, approximately 150 proteins on the plasma membrane are attached to the cell surface by GPI anchors, which confer specific properties on proteins, such as association with membrane microdomains. The structures of lipid and glycan moieties on GPI anchors are remodeled during biosynthesis and after attachment to proteins. The remodeling processes are critical for transport and microdomain-association of GPI-anchored proteins. Here, we describe the structural remodeling of GPI anchors and genes required for the processes in mammals, yeast, and trypanosomes. |
| Keywords: | Glycosylphosphatidylinositol Remodeling Microdomain Lipid raft Endoplasmic reticulum Golgi |
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