Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1 |
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| Authors: | Yiming Chang Gabriel Schlenstedt Andreas Beck |
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| Affiliation: | a Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Universität des Saarlandes, 66421 Homburg, Germany
b Medizinische Biochemie und Molekularbiologie, Medizinische Fakultät, Universität des Saarlandes, 66421 Homburg, Germany |
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| Abstract: | Transient receptor potential (TRP) channels are found among mammals, flies, worms, ciliates, Chlamydomonas, and yeast but are absent in plants. These channels are believed to be tetramers of proteins containing six transmembrane domains (TMs). Their primary structures are diverse with sequence similarities only in some short amino acid sequence motifs mainly within sequences covering TM5, TM6, and adjacent domains. In the yeast genome, there is one gene encoding a TRP-like sequence. This protein forms an ion channel in the vacuolar membrane and is therefore called Yvc1 for yeast vacuolar conductance 1. In the following we summarize its prominent features. |
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| Keywords: | DIDS, 4,4-diisothiocyanato-stilbene-2,2-disulfonic acid DTT, dithiothreitol GFP, green fluorescent protein GOF, gain-of-function InsP3, inositol 1,4,5-triphosphate Pmc1, vacuolar Ca2+-ATPase TM, transmembrane domain TRP, transient receptor potential Vcx1, vacuolar Ca2+/H+ exchanger Vh, holding potential Yvc1, yeast vacuolar conductance 1 |
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