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The effect of levamisole and levamisole + vitamin C on oxidative damage in rats naturally infected with Syphacia muris |
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| Authors: | Sinan Ince Ismail Kucukkurt |
| Institution: | a Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Afyon Kocatepe, Afyonkarahisar 03200, Turkey b Department of Parasitology, Faculty of Veterinary Medicine, University of Afyon Kocatepe, Afyonkarahisar 03200, Turkey c Department of Biochemistry, Faculty of Veterinary Medicine, University of Afyon Kocatepe, Afyonkarahisar 03200, Turkey d Department of Biochemistry, Institute of Health Sciences, University of Afyon Kocatepe, Afyonkarahisar 03200, Turkey |
| Abstract: | This study was performed to determine the effects of levamisole and levamisole + vitamin C against Syphacia muris naturally infection in rats and to detect its effect on the oxidative parameters in blood and tissues of host. For this purpose, natural infection was diagnosed using the cellophane tape method on the perianal region of rats. Infected rats (total 18) were divided into three groups. On the other hand six without helminth rats were used in this study as negative control group. Group 2 was given an orally levamisole HCl treatment with gastric gavage at a dose level of 20 mg/kg body weight in distilled water, every alternate day. Group 3 was given levamisole HCl via gastric gavage at a dose level of 20 mg/kg and vitamin C was given 1 g/L added to the drinking water. All the treatments continued for a period of 7 days. As a result; levamisole administered to rats at dose of 20 mg/kg orally 98.34% was found to be effective against adult S. muris in the rats. In addition to levamisole + vitamin C is effective to alleviate the oxidative damage in rats infected with S. muris. |
| Keywords: | Levamisole Oxidative damage Rat Syphacia muris Vitamin C |
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