Apigenin inhibits larval growth of Caenorhabditis elegans through DAF-16 activation |
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Authors: | Ichiro Kawasaki Bong-Kyeong Oh |
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Affiliation: | Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea |
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Abstract: | Treatment of Caenorhabditis elegans with apigenin, 5,7,4′-trihydroxyflavone, induces larval growth inhibition. To understand the molecular basis of apigenin-induced larval growth inhibition, the effects of apigenin on DAF-16 activity were examined. DAF-16 was activated through nuclear translocation and the mRNA level of sod-3, one of the known DAF-16 target genes, was increased upon apigenin treatment. DAF-16 activity was required for the growth inhibition, since the larval growth retardation upon apigenin treatment was suppressed in daf-16 mutants. These results indicate that apigenin acts as a stressor that activates DAF-16, which in turn inhibits larval growth. |
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Keywords: | Apigenin Flavone DAF-16 DAF-2 Growth inhibition Caenorhabditis elegans |
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