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Adenosine-5′-phosphosulfate kinase is essential for Arabidopsis viability
Authors:Sarah G Mugford
Institution:Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
Abstract:In Arabidopsis thaliana, adenosine-5′-phosphosulfate kinase (APK) provides activated sulfate for sulfation of secondary metabolites, including the glucosinolates. We have successfully isolated three of the four possible triple homozygous mutant combinations of this family. The APK1 isoform alone was sufficient to maintain WT levels of growth and development. Analysis of apk1 apk2 apk3 and apk1 apk3 apk4 mutants suggests that APK3 and APK4 are functionally redundant, despite being located in cytosol and plastids, respectively. We were, however, unable to isolate apk1 apk3 apk4 mutants, most probably because the apk1 apk3 apk4 triple mutant combination is pollen lethal. Therefore, we conclude that APS kinase is essential for plant reproduction and viability.
Keywords:APS  adenosine-5&prime  -phosphosulfate  ATPS  ATP sulfurylase  APR  adenosine-5&prime  -phosphosulfate reductase  APK  APS kinase  PAPS  3&prime  -phosphoadenosine-5&prime  -phosphosulfate  SOT  sulfotransferase  GFP  green fluorescent protein  PSK  phytosulfokine
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