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The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO |
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| Authors: | Hyewon Chung Ae-kyeong Kim Sun-Ah Jung Kweon Yu Joon H. Lee |
| Affiliation: | a Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea b Aging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea c Myunggok Eye Research Institute, Kim’s Eye Hospital, Konyang University College of Medicine, Seoul, Republic of Korea d Department of Environmental Engineering, Chosun University, Gwangju, Republic of Korea |
| Abstract: | Methionine sulfoxide reductase A (msrA) was previously found to increase resistance to oxidative stress and longevity in animals. We identified Drosophila msrA (dmsrA), a Drosophila homolog of human msrA, as a downstream effector of forkhead box O (FOXO) signaling in Drosophila, which enhances resistance to oxidative stress and increases survival under stressed conditions. Additionally, overexpression of dmsrA in neurons extended the lifespan of flies. Moreover, overexpression of dmsrA in fat body cells caused FOXO to translocate to the nucleus, implying that this possible positive feedback loop between dmsrA and FOXO could potentiate the antioxidant activity of dmsrA and increase the lifespan in Drosophila. |
| Keywords: | JNK, c-Jun N-terminal kinase dFOXO, Drosophila FOXO dmsrA, Drosophila msrA FOXO, forkhead box O msrA, methionine sulfoxide reductase A Prx II, Peroxiredoxin II UAS, upstream activator sequence GMR, glass multiple reporter |
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