Quality control: another player joins the ERAD cast |
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| Authors: | Lord J Michael Roberts Lynne M Stirling Colin J |
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| Affiliation: | Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK. |
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| Abstract: | The quality control system known as ERAD removes misfolded proteins from the ER to the cytosol for degradation. The AAA ATPase Cdc48p and ubiquitin ligases play crucial roles; their relationship has been unclear, but recent work has shown that the membrane protein Ubx2p links their functions in yeast. |
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