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Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells |
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| Authors: | Anja Völzke Alexander Koch Dagmar Meyer zu Heringdorf Andrea Huwiler Josef Pfeilschifter |
| Institution: | 1. Pharmazentrum Frankfurt/ZAFES, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany;2. Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, CH-3011 Bern, Switzerland |
| Abstract: | Understanding the mechanisms of sphingosine 1-phosphate (S1P)-induced cyclooxygenase (COX)-2 expression and prostaglandin E2 (PGE2) formation in renal mesangial cells may provide potential therapeutic targets to treat inflammatory glomerular diseases. Thus, we evaluated the S1P-dependent signaling mechanisms which are responsible for enhanced COX-2 expression and PGE2 formation in rat mesangial cells under basal conditions. Furthermore, we investigated whether these mechanisms are operative in the presence of angiotensin II (Ang II) and of the pro-inflammatory cytokine interleukin-1β (IL-1β). |
| Keywords: | AA arachidonic acid ActD actinomycin D Ang II angiotensin II CLX celecoxib COX cyclooxygenase HuR human antigen R IL-1β interleukin-1β MAPK mitogen-activated protein kinase MEK MAPK kinase NAC N-acetylcystein PGE2 prostaglandin E2 PLA2 group II phospholipase 2a PTX pertussis toxin ROCK Rho-dependent kinase S1P sphingosine 1-phosphat S1PR S1P receptors SK sphingosine kinase |
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