tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation

Authors:	Songtao Li Jiaxin Li Chen Shen Ximei Zhang Shan Sun Michael Cho Changhao Sun Zhenyuan Song

Affiliation:	1. Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA;2. Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150081, PR China;3. Department of Pathology, University of Illinois Medical Center, Chicago, IL 60612, USA;4. Department of Bioengineering, College of Engineering, University of Illinois at Chicago, IL 60607, USA

Abstract:

Keywords:	AMPK, adenosine monophosphate-activated protein kinase ARE, antioxidant response element Baf, bafilomycin A1 BSA, bovine serum albumin CaMKK2, Calcium/calmodulin-dependent protein kinase kinase 2 CQ, chloroquine EBSS, amino acid and serum depletion medium ER, endoplasmic reticulum ERK, extracellular signal-regulated kinases FFAs, free fatty acids JNK, c-Jun N-terminal kinase HO-1, heme oxygenase 1 Keap1, Kelch-like ECH-associated protein 1 LC3, microtubule associated protein 1 (MAP1) light chain 3 LKB1, liver kinase B1 mTOR, mammalian target of rapamycin NAFLD, non-alcohol fatty liver diseases Nrf2, nuclear factor (erythroid-derived 2)-like 2 PP2A, protein phosphatase 2A ROS, reactive oxygen species SFAs, saturated fatty acids tBHQ, tert-butylhydroquinone
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