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Searching for a successful HDL-based treatment strategy |
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| Authors: | Srinivasa T Reddy Mohamad Navab GM Anantharamaiah Alan M Fogelman |
| Institution: | 1. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA;2. Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA;3. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA;4. Department of Medicine, University of Alabama at Birmingham, AL 35294, USA |
| Abstract: | Despite strong evidence that HDL-cholesterol levels predict atherosclerotic events in a population, attempts at using an HDL-based treatment strategy have not yet been successful. Most of the efforts to date have focused on raising plasma HDL-cholesterol levels. This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I mimetic peptides. The story of these peptides spans decades and illustrates the remarkable complexity of HDL-based treatment strategies, but suggests that such a strategy may still be successful. |
| Keywords: | ApoA-I apolipoprotein A-I CHD coronary heart disease EV transgenic tomatoes constructed with an empty vector FGF Fibroblast Growth Factor FGFR1 FGF Receptor 1 FPLC fast performance liquid chromatography HDL high density lipoprotein HIF-1α hypoxia-inducible factor-1α LDL low density lipoprotein LDLR&minus /&minus LDL receptor null LPA lysophosphatidic acid MCP-1 Monocyte chemoattractant protein 1 MnSOD manganese superoxide dismutase SQ subcutaneous injection SR-A scavenger receptor A Tg6F transgenic 6F tomatoes TLR toll-like receptor VEGF Vascular Endothelial Growth Factor VEGFR2 VEGF Receptor 2 WD Western diet |
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