Selectivity of latrotoxin channel in lipid bilayers]

It is established that high initial K-TEA and Ca2(+)-K+ selectivity of channel form by latrotoxin in lipid bilayers (LT-channel) may be reduced by lowering the pH value and by increasing electrolytes concentration of solution. It is suggested that LT-channel is water-filled pore cation selectivity which is defined by the electrostatic potential on the mouth of the channel, which is induced by the ionogenic group of toxin.