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Assessment of the Target Engagement and d-Serine Biomarker Profiles of the d-Amino Acid Oxidase Inhibitors Sodium Benzoate and PGM030756 |
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| Authors: | Howley Eimear Bestwick Michael Fradley Rosa Harrison Helen Leveridge Mathew Okada Kengo Fieldhouse Charlotte Farnaby Will Canning Hannah Sykes Andy P Merchant Kevin Hazel Katherine Kerr Catrina Kinsella Natasha Walsh Louise Livermore David G Hoffman Isaac Ellery Jonathan Mitchell Phillip Patel Toshal Carlton Mark Barnes Matt Miller David J |
| Institution: | 1.Takeda Cambridge Ltd, 418 Cambridge Science Park, Milton Road, Cambridge, Cambridgeshire, CB4 0PA, UK ;2.Biomolecular Research Laboratories, Shonan Research Center, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 25108555, Japan ;3.Takeda California Inc., 10410 Science Center Dr, San Diego, CA, 92121, USA ; |
| Abstract: | Neurochemical Research - Irregular N-methyl-d-aspartate receptor (NMDAR) function is one of the main hypotheses employed to facilitate understanding of the underlying disease state of... |
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