| Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders? |
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| 引用本文： | Inui A. Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?[J]. Molecular medicine today, 1999, 5(2): 79-85. DOI: 10.1016/S1357-4310(98)01395-1 |
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| 作者姓名： | Inui A |
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| 摘 要： |
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Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders? |
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| Inui A. Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?[J]. Molecular medicine today, 1999, 5(2): 79-85. DOI: 10.1016/S1357-4310(98)01395-1 |
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| Authors: | Inui A |
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| Affiliation: | Second Dept of Internal Medicine, Kobe University School of Medicine, Japan. inui@med.kobe-u.ac.jp |
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| Abstract: | Anorexia and body weight loss are characteristic of many diseases, including cancer and AIDS. Recent studies indicate that inflammatory cytokines, such as interleukin 1, the interleukin 6 subfamily and tumor necrosis factor, induce anorexia and cachexia by inhibiting the normal adaptive feeding response to energy deficits. Here, I discuss the evidence for and against a central role for neuropeptide Y and leptin in anorexia and cachexia. |
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