The molecular machinery of resurgent sodium current revealed |
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| Authors: | Bean Bruce P |
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| Affiliation: | Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. |
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| Abstract: | Some TTX-sensitive sodium channels open transiently during recovery from inactivation, generating a "resurgent" sodium current that flows immediately following action potentials. In this issue of Neuron, Grieco and colleagues present evidence that resurgent sodium current results from a novel form of inactivation in which the cytoplasmic tail of the beta4 subunit acts as a classic open-channel blocker. |
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