THE BIOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF 6-AMINODOPAMINE: SIMILARITY WITH 6-HYDROXYDOPAMINE |
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| Authors: | R E Heikkila Catherine Mytilineou L J Cote G Cohen |
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| Institution: | Clinical Research Center for Parkinson's and Allied Diseases, College of Physicians and Surgeons of Columbia University, 640 West 168th Street, New York, NY 10032, U.S.A. |
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| Abstract: | 6-aminodopamine was injected intraperitoneally into male Swiss–Webster mice. At 72 h post injection 6-aminodopamine had caused a reduction in the endogenous content of heart norepinephrine, a decrease in the capacity of heart slices to accumulate 3H]-norepinephrine in vitro, and a virtual disappearance of the adrenergic plexus of the mouse iris as viewed by fluorescence histochemistry. Similar data were obtained with the same dose of 6-hydroxydopamine. These data suggest that 6-aminodopamine causes a destruction of sympathetic nerve terminals. Model experiments showed that 6-aminodopamine, like 6-hydroxydopamine, generated H2o2both in vitro and in vivo. 6-Aminodopamine, like 6-hydroxydopamine, also blocked the accumulation of 3H]dopamine into slices of rat brain in vitro. |
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