| 外泌体环状RNA在肿瘤微环境中的研究进展 |
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| 引用本文： | 唐梦甜,周菊梅,廖前进,周钰娟,熊炜,李桂源,唐艳艳,聂少麟. 外泌体环状RNA在肿瘤微环境中的研究进展[J]. 生物化学与生物物理进展, 2021, 48(2): 135-146 |
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| 作者姓名： | 唐梦甜 周菊梅 廖前进 周钰娟 熊炜 李桂源 唐艳艳 聂少麟 |
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| 作者单位： | 2）湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院，长沙 410013,2）湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院，长沙 410013,2）湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院，长沙 410013,2）湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院，长沙 410013,3）中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078,3）中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078,2）湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院，长沙 410013,2）湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院，长沙 410013 |
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| 基金项目： | 国家自然科学基金（81672683，81672993，81672688，81972636，81872281，81472595），湖南省自然科学基金（2018JJ3634），湖南省卫生健康委科研计划项目（20201772）和长沙市科技局科研计划项目（kq1901071，kq1901072） |
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| 摘 要： | 外泌体是细胞分泌的30～150 nm的细胞外囊泡,在肿瘤微环境(tumor microenvironment,TME)中介导细胞间通讯.环状RNA (circular RNA,circRNAs)是一类由前体mRNA (precursor mRNA,pre-mRNA)反向剪接生成的非编码RNA(non-coding RNA,ncRNA),在外泌体中富集且表达稳定.本文主要讨论外泌体起源和circRNAs在外泌体中的分选调控机制,阐述外泌体circRNAs在肿瘤微环境各个阶段中的作用与机制,包括血管生成、EMT、耐药等.最后,本文探讨外泌体circRNAs作为肿瘤标志物和治疗靶点的临床应用前景与价值.
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| 关 键 词： | 外泌体环状RNA 肿瘤微环境 临床应用前景 |
| 收稿时间： | 2020-06-12 |
| 修稿时间： | 2020-08-04 |
Research Progress on Exosomal Circular RNA in Tumor Microenvironment |
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| TANG Meng-Tian,ZHOU Ju-Mei,LIAO Qian-Jin,ZHOU Yu-Juan,XIONG Wei,Li Gui-Yuan,TANG Yan-Yan and NIE Shao-Lin. Research Progress on Exosomal Circular RNA in Tumor Microenvironment[J]. Progress In Biochemistry and Biophysics, 2021, 48(2): 135-146 |
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| Authors: | TANG Meng-Tian ZHOU Ju-Mei LIAO Qian-Jin ZHOU Yu-Juan XIONG Wei Li Gui-Yuan TANG Yan-Yan NIE Shao-Lin |
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| Affiliation: | 2)Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China,2)Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China,2)Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China,2)Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China,3)The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China,3)The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China,2)Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China,2)Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China |
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| Abstract: | Exosomes are extracellular vesicles (30-150nm) that are secreted into a various of bodily fluids and interstitial space by all types of cells. Circular RNAs (circRNAs) are a class of non-coding RNA (ncRNA) generated from the precursor mRNA (pre-mRNA) backsplicing process. Recent evidence suggests that circRNAs enriched in exosome, and play an important role in tumor microenvironment. In this review, we discuss our claim that the biogenesis of exosomal circRNAs, including the regulation mechanism of circRNAs sorting into exosomes and releasing of exosomes. Then, we elucidated the role and mechanism of exosomal circRNAs regulate EMT, cytoskeleton, angiogenesis, metabolism and inflammation, immunity and drug resistance in the tumor microenvironment. Finally, we discussed the clinical application prospects and value of exosomal circRNAs as tumor markers and therapeutic targets. |
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| Keywords: | exosomal circRNAs tumor microenvironment clinical application prospect |
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