金属有机框架纳米酶的研究进展

纳米酶作为一种具有类酶活性的纳米材料,与天然酶相比,具有制备过程简单、受外界环境干扰小、对酸碱和温度具有较好的耐受性等优点.金属有机框架(metal-organic frameworks,MOFs),即多孔配位聚合物,具有结构多样性、高比表面积、孔隙率可控等独特性质.因有序框架的保护以及结构可调控的性质,基于MOFs构建的纳米酶受到研究人员的广泛关注.本文综述不同类型MOFs基的纳米酶,主要从原始MOFs、化学修饰的MOFs、MOFs基复合材料和MOFs衍生物等四大方面进行论述;随后,对4种类型MOFs基纳米酶的构建特点和生化分析应用进行归纳和比较;最后对其当前面临的挑战和未来的发展趋势进行讨论.

Recent Advances in Metal-Organic Frameworks-Based Nanozymes

A kind of nanomaterials with enzyme-mimicking catalytic activity, named as nanozymes, have attracted the attention of researchers. Compared with natural enzymes, nanozymes exhibit the advantages of simple production, low cost and good stability. As a new class of porous coordination polymers, metal-organic frameworks (MOFs) possess many attractive properties, such as structural diversity, pore size tailorability, high specific surface area, and controllable porosity. MOFs-based nanozymes are attracting growing attention because of protection of the ordered framework and the adjustable structure. In this review, we summarize the construction of different types of MOFs-based nanozymes, including pristine MOFs, MOFs with modification, MOF-based composites, and MOF derivatives. Then, the typical applications of MOF-based nanozymes in the detection of various analytes are reviewed. We also summarized and compared the characteristic of MOFs-based nanozymes in different construction types. Finally, the current challenges and future developments of MOFs-based nanozyme are also discussed.