Molecular structural differences between type-2-diabetic and healthy glycogen |
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Authors: | Sullivan Mitchell A Li Jiong Li Chuanzhou Vilaplana Francisco Stapleton David Gray-Weale Angus A Bowen Stirling Zheng Ling Gilbert Robert G |
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Affiliation: | Centre for Nutrition & Food Sciences, The University of Queensland , Brisbane, Qld 4072, Australia. |
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Abstract: | Glycogen is a highly branched glucose polymer functioning as a glucose buffer in animals. Multiple-detector size exclusion chromatography and fluorophore-assisted carbohydrate electrophoresis were used to examine the structure of undegraded native liver glycogen (both whole and enzymatically debranched) as a function of molecular size, isolated from the livers of healthy and db/db mice (the latter a type 2 diabetic model). Both the fully branched and debranched levels of glycogen structure showed fundamental differences between glycogen from healthy and db/db mice. Healthy glycogen had a greater population of large particles, with more α particles (tightly linked assemblages of smaller β particles) than glycogen from db/db mice. These structural differences suggest a new understanding of type 2 diabetes. |
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