Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes |
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| Authors: | Dušan Kordiš Vito Turk |
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| Institution: | (1) Department of Molecular and Biomedical Sciences, J. Stefan Institute, Ljubljana, Slovenia;(2) Department of Biochemistry and Molecular and Structural Biology, J. Stefan Institute, Ljubljana, Slovenia |
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| Abstract: | Background The cystatin superfamily comprises cysteine protease inhibitors that play key regulatory roles in protein degradation processes.
Although they have been the subject of many studies, little is known about their genesis, evolution and functional diversification.
Our aim has been to obtain a comprehensive insight into their origin, distribution, diversity, evolution and classification
in Eukaryota, Bacteria and Archaea. |
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