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Heterogeneity of leukotriene receptors in guinea-pig trachea |
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| Authors: | R D Krell B S Tsai A Berdoulay M Barone R E Giles |
| Abstract: | The selective leukotriene (LT) antagonist FPL 55712 antagonized the contractile activity of synthetic LTD4 and E4 on guinea-pig trachea. Schild analysis of the antagonism provided evidence for two distinct receptors for LTD4: one with significantly higher affinity for FPL 55712 than the other. LTE4 appears to interact preferentially with the high affinity receptor. |
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