Anomalous cellular proliferation in vitro associated with Huntington's disease |
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| Authors: | David Kirk Jennifer M Parrington Gerald Corney Jean M W Bolt |
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| Institution: | (1) The Galton Laboratory, Department of Human Genetics, University College London, England;(2) Hartwood Hospital, Shotts, Lanarkshire, UK;(3) Present address: Department of Hormone Biochemistry, Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, P.O. Box No. 123, WC 2A 3PX London, England |
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| Abstract: | Summary Detailed growth analyses of cultured skin fibroblasts from two patients with Huntington's Disease (HD) were compared with those from controls matched for age and sex. In contrast to control cells, HD fibroblasts plated more efficiently at the low seeding densities used. Subsequent exponential growth of HD cultures was more stable towards routine trypsinisation than that of controls. However, the most striking feature of HD cultures was their ability to grow to significantly higher cell saturation densities. Experiments with trypsinised and untrypsinised cultures imply an inherent alteration in the HD cell membrane. |
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