PAMPer and tRIGer: ligand-induced activation of RIG-I |
| |
Authors: | Bowzard J Bradford Davis William G Jeisy-Scott Victoria Ranjan Priya Gangappa Shivaprakash Fujita Takashi Sambhara Suryaprakash |
| |
Institution: | 1 Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta GA, 30333, United States 2 Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawara Sakyo, Kyoto 606-8507, Japan |
| |
Abstract: | Retinoic-acid-inducible gene-I (RIG-I) is an important component of the innate immune response to many RNA viruses that limits viral replication until adaptive immunity becomes available to clear the infection. Upon binding to the nucleic acid genomes and replication intermediates of these viruses, RIG-I undergoes a complex activation process that involves post-translational modifications and structural rearrangements. Once activated, RIG-I upregulates well-studied signal transduction pathways that lead to the production of type-I interferons (IFNs) and a large variety of antiviral IFN-stimulated genes. Thus, an effective antiviral response is dependent on the interaction between pathogen-derived ligands and RIG-I. Recent work has begun to clarify the required characteristics of RIG-I activators and is setting the stage for the identification of authentic ligands used during viral infection. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|