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A functional type I topoisomerase from Pseudomonas aeruginosa
Authors:Teesta Jain  Benjamin J Roper  Anne Grove
Affiliation:(1) Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA;(2) University of Texas Medical Branch, Galveston, TX, USA
Abstract:

Background  

Pseudomonas aeruginosa encodes a putative topoisomerase with sequence similarity to the eukaryotic type IB topoisomerase from Vaccinia virus. Residues in the active site are conserved, notably Tyr292 which would be predicted to form the transient covalent bond to DNA.
Keywords:
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