Polymorphism of the paraoxonase (PON-1) gene in the Slavonic part of the Kharkiv population |
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| Authors: | A. K. Pochernyaev T. V. Tyzhnenko M. Yu. Gorshunska V. V. Poltorak L. A. Atramentova |
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| Affiliation: | 1.GU Danilevskii Institution of Problems of Endocrine Pathology AMS Ukraine,Kharkiv,Ukraine;2.Kharkiv medical academy of post-graduate education,Kharkiv,Ukraine;3.Karazin national university,Kharkiv,Ukraine |
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| Abstract: | We studied the polymorphism of gene PON-1 in 192 positions of amino acid sequence of enzyme paraoxonase 1, which is connected with isoenzymes R and Q. We analyzed 109 blood samples of habitants of Kharkiv (78 men and 31 women), 84 Ukrainians and 25 Russians. The frequency of the Q allele was p Q = 0.67, and R allele − p R = 0.33. The differences among Ukrainians and Russians as well as among men and women were not significant. The genotype’s frequency distribution in the Slavonic part of the Kharkiv population corresponds to the panmictic population. |
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