The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough |
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Authors: | Heidelberg John F Seshadri Rekha Haveman Shelley A Hemme Christopher L Paulsen Ian T Kolonay James F Eisen Jonathan A Ward Naomi Methe Barbara Brinkac Lauren M Daugherty Sean C Deboy Robert T Dodson Robert J Durkin A Scott Madupu Ramana Nelson William C Sullivan Steven A Fouts Derrick Haft Daniel H Selengut Jeremy Peterson Jeremy D Davidsen Tanja M Zafar Nikhat Zhou Liwei Radune Diana Dimitrov George Hance Mark Tran Kevin Khouri Hoda Gill John Utterback Terry R Feldblyum Tamara V Wall Judy D Voordouw Gerrit Fraser Claire M |
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Affiliation: | The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA. dvu@tigr.org |
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Abstract: | Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the 'hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-III protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration. |
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