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Lanostane-triterpenoids from the fungus Phellinus gilvus |
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| Authors: | Hui-Kang Liu Tun-Tschu Chang Lie-Chwen Lin |
| Institution: | a National Research Institute of Chinese Medicine, 155-1, Li-Nong St., Sec. 2, Taipei 112, Taiwan b Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan c Division of Forest Protection, Taiwan Forestry Research Institute, Taipei, Taiwan d Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan |
| Abstract: | Triterpenoids gilvsins A-D (1-4), with oxygenated lanostane skeletons, were isolated from the fruiting body of Phellinus gilvus, together with two known compounds, 24-methylenelanost-8-ene-3β, 22-diol and 5α-ergosta-7,22-diene-3-one. The structures of 1-4 were deduced from analysis of spectroscopic data. The absolute configuration at C-22 of 1 was determined by the modified Mosher’s method and the structure of 1 was confirmed by X-ray analysis. The hypoglycemic activities of the crude extract of P. gilvus and the isolated compounds were also evaluated, but were not promising for further investigation. |
| Keywords: | Phellinus gilvus Hymenochaetaceae Chemical constituent Triterpenoid Gilvsins |
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