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Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia |
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| Authors: | Jian-Chao Chen Lu Lu Ming-Hua Qiu Yong-Tang Zheng Xian-Min Zhang Zhong-Rong Li |
| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China b Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China c Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China |
| Abstract: | Chemical investigation of the vines and leaves of Momordica charantia resulted in isolation of fourteen cucurbitane triterpenoids, kuguacins F-S (1-14), including two pentanorcucurbitacins (6 and 7), one octanorcucurbitacin (8), and two trinorcucurbitacins (11 and 12), along with six known analogues. Their structures were elucidated on the basis of extensive spectroscopic and single-crystal X-ray diffraction analyses. Compounds 1-14 exhibited weak anti-HIV-1 activities in vitro. |
| Keywords: | Momordica charantia Cucurbitaceae Cucurbitane triterpenoids Kuguacins F-S |
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