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Antibacterial endiandric acid derivatives from Beilschmiedia anacardioides |
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| Authors: | Jean Rodolphe Chouna Bruno Ndjakou Lenta Krishna Prasad Devkota Hans-Georg Stammler Norbert Sewald |
| Affiliation: | a Department of Organic Chemistry, University of Yaounde 1, P.O. Box 812, Yaoundé, Cameroon b Department of Chemistry, University of Dschang, P.O. Box 371, Dschang, Cameroon c Department of Chemistry, Higher Teachers’ Training College, University of Yaoundé 1, P.O. Box 47, Yaoundé, Cameroon d Chemistry Department, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany e Chemistry Department, Inorganic and Structural Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany |
| Abstract: | Three endiandric acid derivatives, beilschmiedic acids A, B and C were isolated from the stem bark of Beilschmiedia anacardioides together with the known β-sitosterol. Their structures were established by means of modern spectroscopic techniques. The relative configuration of compound 1 was determined by single crystal X-ray analysis. The antibacterial activities of compounds A,B,C were evaluated in vitro against five strains of microbes. Compound C showed strong activity against Bacillus subtilis, Micrococcus luteus and Streptococcus faecalis (MICs below 23 μM). This Compound was more active than the reference antibiotic ampicillin against B. subtilis and M. luteus. |
| Keywords: | Beilschmeidia anacardioides Lauraceae Beilschmiedic acids A, B and C X-ray analysis Antibacterial |
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