|
|||||
|
|
Cytotoxic benzil and coumestan derivatives from Tephrosia calophylla |
|
| Authors: | Seru Ganapaty Guttula Veera Kantha Srilakshmi Hafizur Rahman Reto Brun |
| Institution: | a Pharmacognosy and Phytochemistry Division, Department of Pharmaceutical, Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India b Institute for Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany c Swiss Tropical Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland |
| Abstract: | A benzil, calophione A, 1-(6′-Hydroxy-1′,3′-benzodioxol-5′-yl)-2-(6″-hydroxy-2″-isopropenyl-2″,3″-dihydro-benzofuran-5″-yl)-ethane-1,2-dione and three coumestan derivatives, tephcalostan B, C and D were isolated from the roots of Tephrosia calophylla. Their structures were deduced from spectroscopic data, including 2D NMR 1H-1H COSY and 13C-1H COSY experiments. Compounds were evaluated for cytotoxicity against RAW (mouse macrophage cells) and HT-29 (colon cancer cells) cancer cell lines and antiprotozoal activity against various parasitic protozoa. Calophione A exhibited significant cytotoxicity with IC50 of 5.00 (RAW) and 2.90 μM (HT-29), respectively. |
| Keywords: | Tephrosia calophylla Fabaceae Bioactive products Benzil Coumestan derivatives Cytotoxicity Antiprotozoal activity |
| 本文献已被 ScienceDirect 等数据库收录！ | |