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Aromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36 |
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| Authors: | Porntep Chomcheon Suthep Wiyakrutta Nattaya Ngamrojanavanich Surapong Kengtong Somsak Ruchirawat Prasat Kittakoop |
| Institution: | a Chulabhorn Research Institute, Vibhavadi-Rangsit Highway, Laksi, Bangkok 10210, Thailand b Program of Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand c Department of Microbiology, Faculty of Science, Mahidol University, and the Center of Bioactive Natural Products from Marine Organisms and Endophytic Fungi (BNPME), Bangkok 10400, Thailand d Department of Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, and the Center of Bioactive Natural Products from Marine Organisms and Endophytic Fungi (BNPME), Bangkok 10330, Thailand e Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand f Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand g Chulabhorn Graduate Institute, and the Center for Environmental Health, Toxicology and Management of Chemicals (ETM), Vibhavadi-Rangsit Highway, Bangkok 10210, Thailand h Chulabhorn Research Centre, Institute of Science and Technology for Research and Development, Mahidol University, Thailand |
| Abstract: | Isolation of a broth extract of the endophytic fungus Corynespora cassiicola L36 afforded three compounds, corynesidones A (1) and B (3), and corynether A (5), together with a known diaryl ether 7. Compounds 1, 3, 5, and 7 were relatively non-toxic against cancer cells, and inactive toward normal cell line, MRC-5. Corynesidone B (3) exhibited potent radical scavenging activity in the DPPH assay, whose activity was comparable to ascorbic acid. Based on the ORAC assay, compounds 1, 3, 5, and 7 showed potent antioxidant activity. However, the isolated natural substances and their methylated derivatives (1−8) neither inhibited superoxide anion radical formation in the XXO assay nor suppressed TPA-induced superoxide anion generation in HL-60 cell line. Corynesidone A (1) inhibited aromatase activity with an IC50 value of 5.30 μM. |
| Keywords: | Corynespora cassiicola Endophytic fungi Depsidone Diaryl ether Aromatase inhibitor Radical scavenging Antioxidant activity Cytotoxic activity |
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