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Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb |
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| Authors: | Ozlem Demirkiran Hayrettin Beynek M. Iqbal Choudhary |
| Affiliation: | a Department of Chemistry, Faculty of Science and Arts, Trakya University, Edirne 22030, Turkey b Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan c H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan |
| Abstract: | The phytochemical investigation of the ethyl acetate extract of Hypericum thasium has led to the characterization of four benzophenone derivatives 1-4, a known benzophenone 5 and four known flavonoids, quercetin (6), quercitrin (7), isoquercetin (8), and 3, 8′′-biapigenin (9). Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds towards the production of reactive oxygen species (ROS) by human polymorphoneutrophils (PMNs). The assay results showed that benzophenones 1 and 3 are extracellular inhibitors of ROS production, while flavonoids 6, 8, and 9 can modulate intracellular ROS production. |
| Keywords: | Hypericum thasium Guttiferae Benzophenone glycosides Reactive oxygen species (ROS) Inhibition of ROS |
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