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Dimeric 1,4-benzoquinone derivatives and a resorcinol derivative from Ardisia gigantifolia |
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| Authors: | Hongwei Liu Feng Zhao Manyuan Wang Yisong Zhao Feng Qiu |
| Institution: | a Key Lab of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, PR China b School of Chemical Biology and Pharmaceutical Sciences 62#, Capital University of Medical Sciences, No.10 Xitoutiao, You An Men Beijing 100069, PR China c School of Pharmacy, Yantai University, No. 32 Road QingQuan, Laishan District, Yantai 264005, PR China d Key Laboratory of Medicinal Chemical Resources and Molecular Engineering, Guangxi Normal University, No.15 Yucai Road, Guilin 541004, PR China e Department of Natural Product Chemistry, Shenyang Pharmaceutical University, No. 103 Wenhua-Road, Shenyang 110016, PR China |
| Abstract: | Naturally occurring dimeric 1,4-benzoquinone derivatives, belamcandaquinones F, G, H, and I, as well as one resorcinol derivative and four known compounds, were isolated from rhizomes of Ardisia gigantifolia. Their structures were established by means of spectroscopic analyses. All compounds were tested against cell lines PC-3, EMT6, A549, Hela, RM-1, and SGC7901 for cytotoxicity in vitro. In comparison with cisplatin, compounds 5 and 6 showed a strong cytotoxicity with IC50 values less than 30 μM for most cell lines tested. |
| Keywords: | Ardisia gigantifolia Myrsinaceae 1 4-Benzoquinone derivative Resorcinol derivative Cytotoxicity |
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