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Triterpenoids with antimicrobial activity from Drypetes inaequalis |
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| Authors: | Simon Suh Awanchiri Jovita Chi Shirri Guy Merlin Nguenang Zacharias T. Fomum Philippe Verite Jean Wandji |
| Affiliation: | a Department of Organic Chemistry, University of Yaounde-1, Faculty of Science, P.O. Box 812, Yaounde, Cameroon b Department of Vegetal Biology and Physiology, University of Yaounde-1, Faculty of Science, P.O. Box 812, Yaounde, Cameroon c Laboratoire de Pharmacognosie, UMR/CNRS N° 8638, Université Paris Descartes, Faculté des Sciences Biologiques et Pharmaceutiques, 4-Avenue de l’Observatoire, 75006 Paris, France d Laboratoire de Pharmacognosie, UFR de Médecine Pharmacie Rouen, 22-Bld Gambetta, 76183 Rouen Cedex 1, France e Laboratoire de Chimie Analytique, UFR de Médecine Pharmacie Rouen, 22-Bld Gambetta, 76183 Rouen Cedex 1, France |
| Abstract: | The air-dried stems and ripe fruit of Drypetes inaequalis Hutch. (Euphorbiaceae) were studied. Four triterpene derivatives, characterized as lup-20(29)-en-3β,6α-diol, 3β-acetoxylup-20(29)-en-6α-ol, 3β-caffeoyloxylup-20(29)-en-6α-ol and 28-β d-glucopyranosyl-30-methyl 3β-hydroxyolean-12-en-28,30-dioate along with 10 known compounds were isolated from the whole stems. One triterpene, characterized as 3α-hydroxyfriedelan-25-al along with six known compounds were isolated from the ripe fruit. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The triterpenes were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria, and two of them appeared to be modestly active. |
| Keywords: | Drypetes inaequalis Euphorbiaceae Stems Fruit Triterpenoid esters Saponins Antimicrobial activity |
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