Four anti-protozoal and anti-bacterial compounds from Tapirira guianensis |
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Authors: | Vincent Roumy,Nicolas Fabre,Bé né dicte Portet,Lucia Acebey,Alexis Valentin |
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Affiliation: | a Université de Toulouse, UMR 152 IRD-Université Paul Sabatier, Toulouse 3, Faculté des Sciences Pharmaceutiques, 31062 Toulouse cedex 9, France b EA 1043, Laboratoire de Pharmacognosie, Université Lille 2, BP 83, F-59006 Lille, France c Laboratoire de Pharmacognosie, Université de Montpellier I, 34093 Montpellier, France |
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Abstract: | Tapirira guianensis is a common tree used in traditional medicine in French Guiana against several infectious diseases (malaria, leishmaniasis, bacteria, etc.). The bioassay-guided purification of CH2Cl2 bark extract led to the isolation of four cyclic alkyl polyol derivatives: 4,6,2′-trihydroxy-6-[10′(Z)-heptadecenyl]-1-cyclohexen-2-one (1a), 1,4,6-trihydroxy-1,2′-epoxy-6-[10′(Z)-heptadecenyl]-2-cyclohexene (1b), 1,4,5,2′-tetrahydroxy-1-[10′(Z)-heptadecenyl]-2-cyclohexene (2), and 1,3,4,6-tetrahydroxy-1,2′-epoxy-6-[10′(Z)-heptadecenyl]-cyclohexane (3). The structures were established on the basis of 1D and 2D NMR analyses. The anti-leishmanial, anti-plasmodial, anti-bacterial (on Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli), and anti-fungal (on Candida albicans) activities of the extracts and of these original compounds were evaluated. Two showed medicinal interest supporting the traditional uses of the plant. The structures were established through spectral analyses of the isolates and their derivatives. |
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Keywords: | Tapirira guianensis Aubl Anacardiaceae Cyclic alkyl polyol derivatives Anti-plasmodial Anti-leishmanial Anti-bacterial Plasmodium falciparum Leishmania amazonensis |
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