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Cassane Diterpenes from Caesalpinia bonduc |
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| Authors: | Prem P Yadav Ranjani Maurya Ashish Arora Sudhir Sinha Ram Raghubir |
| Institution: | a Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India b Drug Target Discovery and Development Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, Uttar Pradesh, India c Molecular and Structural Biology Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, Uttar Pradesh, India d Sophisticated Analytical Instrument Facilities, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, Uttar Pradesh, India e Botany Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, Uttar Pradesh, India f Pharmacology Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, Uttar Pradesh, India |
| Abstract: | Three cassane diterpene hemiketals, caesalpinolide-C, caesalpinolide-D, caesalpinolide-E and one cassane furanoditerpene were isolated from Caesalpinia bonduc. The molecular structures were elucidated using NMR spectroscopy in combination with IR, UV and mass spectral data and relative stereochemistries were determined through ROESY correlation. The isolated compounds were tested for their antiproliferative activity against MCF-7 (breast adenocarcinoma), DU145 (prostate carcinoma), C33A (Cervical carcinoma) and Vero (African green monkey kidney fibroblast) cells. |
| Keywords: | Caesalpinia bonduc Fabaceae Phytochemistry Cassane diterpenes Butenolides Furanoditerpenes Antiproliferative activity |
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