Antiplasmodial halogenated monoterpenes from the marine red alga Plocamium cornutum |
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Authors: | Anthonia F Afolayan Carmen A Lategan John J Bolton |
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Institution: | a Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Artillery Road, Grahamstown 6140, South Africa b Division of Pharmacology, University of Cape Town, Observatory 7925, South Africa c Department of Botany, University of Cape Town, Private Bag, Rondebosch 7701, South Africa |
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Abstract: | In our continuing search for antimalarial leads from South African marine organisms we have examined the antiplasmodial organic extracts of the endemic marine red alga Plocamium cornutum (Turner) Harvey. Two new and three known halogenated monoterpenes were isolated and their structures determined by standard spectroscopic techniques. The 3,7-dimethyl-3,4-dichloro-octa-1,5,7-triene skeleton is common to all five compounds. Interestingly, compounds bearing the 7-dichloromethyl substituent showed significantly higher antiplasmodial activity toward a chloroquine sensitive strain of Plasmodium falciparum. |
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Keywords: | Plocamium cornutum Plocamiaceae Antimalarial Halogenated monoterpene |
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