Steroidal saponins from the whole plants of Agave utahensis and their cytotoxic activity |
| |
| Authors: | Akihito Yokosuka Yoshihiro Mimaki |
| |
| Institution: | Laboratory of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1432-1, Horinouchi, Hachiouji, Tokyo 192-0392, Japan |
| |
| Abstract: | Phytochemical investigation of the whole plants of Agave utahensis Engelm. (Agavaceae) has resulted in the isolation of 15 steroidal saponins (1-15), including five spirostanol saponins (1-5) and three furostanol saponins (11-13). Structures of compounds 1-5 and 11-13 were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. |
| |
| Keywords: | Agave utahensis Engelm Agavaceae Spirostanol saponins Furostanol saponins Cytotoxic activity HL-60 cells |
| 本文献已被 ScienceDirect 等数据库收录！ |
