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The determination of the potency of human tetanus immunoglobulins by an enzyme-linked immunosorbent assay |
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| Authors: | G Gentili C Pini C Collotti |
| Affiliation: | 1. University of South Australia, UniSA Clinical and Health Sciences, Rosemary Bryant AO Research Centre, SA 5000, Australia;2. Australian Nursing and Midwifery Federation (ANMF), National Policy Research Unit (Federal Office), SA, 5000, Australia;3. Australian Nursing and Midwifery Federation (ANMF), Federal Office, Victoria, 3000, Australia |
| Abstract: | A micro enzyme-linked immunosorbent assay has been adapted to the quantitation of specific tetanus antibodies in commercial preparations of human immunoglobulins. The results of the assay are compared with those obtained from the same samples tested by seroneutralization tests in vivo. Statistical analysis of the data shows good correlation between the titres obtained with the two tests. Results obtained by indirect haemagglutination are also reported. It is proposed that all interested laboratories perform the described immunoenzymatic method in vitro for a given period in parallel with the in vivo test to gain sufficient experience of this technique with a view to its use as an alternative to the in vivo test. |
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