Pituitary corticotropin-inhibiting peptide: Properties and use in study of corticotropin action |
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Authors: | CY Lee Margaret Mcpherson Vojtech Licko J Ramachandran |
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Institution: | 1. Hormone Research Laboratory University of California, San Francisco, California 94143 U.S.A.;2. Cardiovascular Research Institute, University of California, San Francisco, California 94143 U.S.A. |
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Abstract: | The biological properties of the naturally occurring pituitary peptide αh7–38-adrenocorticotropin (ACTH) have been investigated. αh7–38-ACTH is devoid of steroidogenic activity but inhibits competitively ACTH-induced steroidogenesis in vitro as well as in vivo. The long-term actions of ACTH on normal and tumor adrenal cells in culture are also antagonized by αh7–38-ACTH. The apparent Ki for the inhibition of cyclic AMP production by αh7–38-ACTH (301 ± 62 nm) was significantly higher than the apparent Ki for the inhibition of corticosterone synthesis (21.6 ± 6.8 nm). Analysis of the inhibition of ACTH-induced steroidogenesis and cyclic AMP production in normal rat adrenocortical cells indicates that two separate receptors may be involved in mediating these responses. |
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