Linear relation between rate and thermodynamic force in enzyme-catalyzed reactions |
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| Authors: | R van der Meer HV Westerhoff K Van Dam |
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| Institution: | Laboratory of Biochemistry, B.C.P. Jansen Institute, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam The Netherlands |
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| Abstract: | Starting from enzyme kinetics, it is shown that generally a linear rather than a proportional relationship exists between rate and free energy changes in biochemical processes. In the derivation the boundary condition of constant substrate plus product is used, which is appropriate for many cellular systems. An example is the ADP plus ATP concentration in mitochondrial oxidative phosphorylation, as is illustrated experimentally. |
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| Keywords: | Enzyme kinetics Thermodynamics Respiration Energy-transducing system Linear flow-force relation (Mitochondria) |
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