Effect of catecholamines and ovarian hormones on cyclic AMP accumulation in rat hypothalamus |
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| Authors: | K P Gunaga K M Menon |
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| Institution: | 1. Reproductive Endocrinology Program Department of Obstetrics and Gynecology The University of Michigan Medical Center Ann Arbor, Michigan 48104 USA;2. Department of Biological Chemistry The University of Michigan Medical Center Ann Arbor, Michigan 48104 USA |
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| Abstract: | Effect of different monoamines and estradiol were studied on cyclic AMP (cAMP) accumulation in hypothalami from 21 day old female rats. Incubation for 5 min with 10?4M epinephrine, norepinephrine or dopamine resulted in an increase in cAMP accumulation in the hypothalamus. Incubation of hypothalamic tissue with estradiol (4 × 10?7M to 2 × 10?5M) also resulted in an increase in cyclic AMP levels. The increase caused by estradiol was observed only after 50 min of incubation period. The estradiol induced increase in cyclic AMP accumulation was abolished by both α and β blockers. These results suggest that the estradiol-induced increase in cyclic AMP may be mediated by a prior increase in catecholamines in the hypothalamic tissue. |
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| Keywords: | To whom correspondence should be addressed |
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