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Synthesis of d-labeled and unlabeled benzoyloxysuccinimides and application to quantitative analysis of peptides and a protein by isotope differential mass spectrometry |
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| Authors: | Zabet-Moghaddam Masoud Shaikh Aarif L Jones Lauren B Niwayama Satomi |
| Institution: | Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA |
| Abstract: | Benzoyloxysuccinimide and its d5-labeled version, which react with amino groups in the N-termini and lysine side chains in proteins, were synthesized and applied to quantitative analysis of peptides and a commercially available protein in combination with a MALDI mass spectrometer. |
| Keywords: | Amino group modifier Stable isotope-labeling Proteomics Mass spectrometry |
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