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Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives |
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| Authors: | Nagarapu Lingaiah Mateti Jhansi Gaikwad Hanmant K Bantu Rajashaker Sheeba Rani M Prameela Subhashini N J |
| Institution: | a Organic Chemistry Division-II, Indian Institute of Chemical Technology (CSIR), Tarnaka, Hyderabad 500607, India b Department of Pharmacy, University College of Technology, Osmania University, Hyderabad 500607, India |
| Abstract: | A new series of 3-phenyl-N-3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents. |
| Keywords: | Nonsterodial anti-inflammatory drugs Pyrazole carboxamide derivative Ibuprofen Celecoxib |
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