|
|||||
|
|
Antiproliferative activity of dmoPTA-Ru(II) complexes against human solid tumor cells |
|
| Authors: | Ríos-Luci Carla León Leticia G Mena-Cruz Adrián Pérez-Roth Eduardo Lorenzo-Luis Pablo Romerosa Antonio Padrón José M |
| Institution: | a BioLab, Instituto Universitario de Bio-Orgánica ‘Antonio González’ (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain b Departamento de Química Inorgánica, Facultad de Química, Universidad de La Laguna, C/Astrofísico Francisco Sánchez 3, 38206 La Laguna, Spain c Área de Química Inorgánica, Facultad de Ciencias Experimentales, Universidad de Almería, 04071 Almería, Spain |
| Abstract: | The biological evaluation of new Ru(II) complexes carrying dmoPTA (dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo3.3.1]nonane) ligands is reported. The results on the biological activity revealed that the organometallic complexes are active against all cell lines with GI50 values in the range 1.1-2.6 μM. When compared to the standard anticancer drug cisplatin, the bimetallic Ru(II) complexes showed a greater activity profile. The cell cycle analysis revealed that the new compounds induced arrest in G1 phase. Contrary to cisplatin, these Ru(II) complexes do not interact with DNA. This result suggests that DNA might not be the key pharmacological target. |
| Keywords: | Ruthenium complexes Hydrosoluble phosphines Antitumor drugs Organometallic drugs Cell cycle arrest |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |