Structure-activity studies of RNA-binding oxazolidinone derivatives |
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Authors: | Maciagiewicz Iwona Zhou Shu Bergmeier Stephen C Hines Jennifer V |
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Affiliation: | Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA |
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Abstract: | The structure-activity relationship of a series of oxazolidinones binding to T-box riboswitch antiterminator RNA has been investigated. Oxazolidinones differentially substituted at C-5 were prepared and the ligand-induced fluorescence resonance energy transfer (FRET) changes in FRET-labeled antiterminator model RNA were assayed. Both qualitative and quantitative analysis of the structure-activity relationship indicate that hydrogen bonding and hydrophobic properties play a significant role in ligand binding. |
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Keywords: | RNA Oxazolidinone Antiterminator T-box riboswitch FRET |
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