Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells |
| |
Authors: | Shin Seo Young Shin Min Cheol Shin Ji-Sun Lee Kyung-Tae Lee Yong Sup |
| |
Affiliation: | Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Republic of Korea |
| |
Abstract: | Sulfuretin is one of major constituents of Rhus verniciflua that exerts anti-inflammatory activities. Some of aurones were synthesized as sulfuretin derivatives and evaluated for their abilities to inhibit NO and PGE2 production in LPS-induced RAW 264.7 cells in order to reveal the relationship. Of the aurones synthesized in the present study, 2h and 2i, which possess C-6 hydroxyl group in A-ring and methoxy substituents in B-ring, more potently inhibited NO and PGE2 production and were less cytotoxic than sulfuretin. |
| |
Keywords: | Sulfuretin Aurone Nitric oxide Prostaglandin E2 Anti-inflammatory |
本文献已被 ScienceDirect PubMed 等数据库收录! |