Osteogenic constituents from Pterospermum acerifolium Willd. flowers |
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Authors: | Dixit Preety Khan Mohd Parvez Swarnkar Gaurav Chattopadhyay N Maurya Rakesh |
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Affiliation: | a Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226001, India b Endocrinology Division, Central Drug Research Institute, CSIR, Lucknow 226001, India |
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Abstract: | Phytochemical investigation of ethanol extracts of the Pterospermumacerifolium flowers led to the isolation and identification of two new flavones, 4′-(2-methoxy-4-(1,2,3-trihydroxypropyl) phenoxy luteolin (1) and 5,7,3′-trihydroxy-6-O-β-d-glucopyranosyl flavone (2), and one new lactone, 3,5-dihydroxyfuran-2(5H)-one (3) along with 14 known compounds (4-17). The structure of compounds 1-17 was established based on MS, 1D and 2D NMR, spectroscopic analysis. Eight of these compounds (1-6, 8 and 9) were assessed for osteogenic activity by using primary cultures of rat osteoblast. The compounds 1, 3 and 4 significantly stimulated osteoblast differentiation and mineralization as evident from a marked increase in expression of alkaline phosphatase and alizarin red-S staining of osteoblasts. |
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Keywords: | Pterospermum acerifolium Pterospermin A Pterospermin B Pterospermin C Osteoblast differentiation |
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